Entity Developer allows you to mix Model-First and Database-First approaches when designing your model. With Update to Database and Update from Database wizards you can easily synchronize your model and database in any direction. For example, you may generate model from the database, then edit it, and apply these changes to the database with Update to Database Wizard.
You can use Mapping AutoSync with models that were generated from database with Database-First approach. You just need to enable automatic synchronization of the storage part and mapping of the model with its conceptual part in the Model Settings dialog box.